Journal of Endocrinology and Reproduction

M. Michael Aruldhas ¹

Affiliations
1 SRBCE, Department of Endocrinology, University of Madras, Taramani Campus, Chennai 600113, IN

Abstract

It is with deep sense of sorrow I pen this obituary for Professor Ben M.J. Pereira, my bench- mate at the Department of Endocrinology, University of Madras, while doing our Ph.D. programme under the supervision of Prof. P. Govindarajulu during the period 1978-1983. Ben (that is how we call him affectionately), the youngest among the research scholars then, and loved by everyone, was always seen with a smiling face. Ben's presence made any gathering live and enjoyable, eased out tensions and strengthened bonds among the members. The famous "7'O clock idea of Ben", which used to be some of his funny solutions to tricky issues of our discussion at our evening tea club meetings, still lingers in my mind. These ideas of Ben used to bring not only laughter amidst us but also transformed tensed evenings enjoyable and made the warring members forget the differences between them.

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M. Michael Aruldhas ¹, N. Kalpana ¹, G. Vengatesh ¹, K. Sakhila Banu ², P. Govindarajulu ¹

Affiliations
1 Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN
2 Ontogenie et Reproduction, CRBR, CHUL, 2705 Boul W Lauira, Laval University Stc Roy, que, GIV 4G2, CA

Abstract

Existing modes of diagnosis and therapy for medullary thyroid carcinoma (MTC) have limitations, informations on the genetics of familial medullary thyroid carcinoma (FMTC), a constituent of multiple endocrine neoplasia II (MEN II) syndrome may help to understand the etiology of the disease and to design gene therapy. Association between specific mutations in ret protooncogene to specific phenotypes of MEN II subjects provide vital line of due for the diagnosis of the disease. Screening of suspected/potent carriers of ret (rearranged during transformation) mutations will help to decide about the time and course of treatment. Gene therapy for MTC appears to be imminent and this review attempts to provide a comprehensive account of informations from more than hundred research articles published in this area.

Keywords

Calcitonin, Familial Medullary Thyrold Carcinoma, Gene Therapy, Immuno Therapy, Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia, Ret Protooncogene.

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M. Michael Aruldhas ¹, G. Rajendiran ¹, S. Subramanian ¹, S. Dharmalingam ¹, P. Govindarajulu ¹

Affiliations
1 Department of Endocrinology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN

Abstract

The effect of 4(R) - 5, 10, Seco 19 - norpregna 4,5 diene 3,10, 20 trione (SECO), a potent inhibitor of 5α-reductase, an intracellular enzyme that converts testosterone to dihydrotestosterone (DHT), on epididymal sperm count and motility was studied in Wistar rats. Administration of (i.m.) 250, 500, 750,1000 μg SECO/Kg b.wt/day to mature rats for 45 days impaired sperm forward motility in a dose dependent manner. Epididymal weight and sperm number decreased in rats treated with 750 and 1000 μg SECO, whereas weight of other accessory organs decreased in rats treated with 1000 μg SECO only. The epididymal histology showed degraded sperm and increased number of clear cells indicating high endocytotic activity, to clear dead sperm, whereas no obvious change was observed in the testicular histology. SECO treatment increased testosterone concentration whereas, it decreased estradiol concentration in circulation and in the epididymal tissue. SECO treatment specifically decreased 5α-reductase in epididymis without affecting the same in the liver, indicating its targeted effect on the epididymis. Thus, the preliminary in vivo study points out that SECO impairs the acquisition of sperm forward motility.

Keywords

Epididymis, 5α-Reductase Inhibitor, SECO, Sperm Fordward Motility.

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R. llangovan ¹, M. Balaganesh ¹, S. Sittadjody ¹, R. Sivakumar ¹, M. Sridhar ¹, R. C. Vignesh ¹, B. Ravi Sankar ¹, J. Arunakaran ¹, K. Balasubramanian ¹, M. Michael Aruldhas ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN

Abstract

In the present investigation, 100 osteoporotic men with 100 age-matched normal were studied for serum sex steroids, parathyroid hormone (PTH), thyroid hormone (T₃), cytokines and bone turnover markers. Serum dihydrotestosterone (DHT) was significantly decreased in osteoporotic men compared with normal. In osteoporotic men, there was a significant increase in serum interleukin (IL)-lalpha. A marked increase in bone formation marker, serum osteocalcin (OCN) and bone resorption marker, serum tartrate-resistant acid phosphatase (TRAP) reflects high bone turnover in osteoporotic men. In conclusion, the present findings point out an important role of DHT in maintaining BMD in men. A strong positive correlation of serum DHT with BMD offers new perspectives in understanding the role of non-aromatizable androgen in the regulation of bone metabolism in men.

Keywords

BMD, Cytokines, DHT.

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M. Michael Aruldhas ¹, M.A. Akbarsha ², Laxmi S. Inamdar ³

Affiliations
1 Secretary, Society for Reproductive Biology and Comparative Endocrinology, Department of Endocrinology, Dr.ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Taramani, Chennai - 600113, India ., IN
2 Biomedical Scientist & Research Coordinator, National College (Autonomous), Tiruchirappalli, Editor-in-Chief, Journal of Endocrinology and Reproduction (JER) of SRBCE, General Secretary, Society for Alternatives to Animal Experiments (SAAE-I), India ., IN
3 Department of Zoology, Karnatak University, Dharwad, Karnataka, India ., IN

Abstract

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